Woman\u27s Place In The Church

https://digitalcommons.acu.edu/crs_books/1296/thumbnail.jp

ENRE 655 Class Project. Development of the Initial Main Parachute Failure Probability for the Constellation Program (CxP) Orion Crew Exploration Vehicle (CEV) Parachute Assembly System (CPAS)

Loss of Crew (LOC) and Loss of Mission (LOM) are two key requirements the Constellation Program (CxP) measure against. To date, one of the top risk drivers for both LOC and LOM has been Orion's Crew Exploration Vehicle (CEV) Parachute Assembly System (CPAS). Even though the Orion CPAS is one of the top risk drivers of CxP, it has been very difficult to obtain any relevant data to accurately quantify the risk. At first glance, it would seem that a parachute system would be very reliable given the track record of Apollo and Soyuz. Given the success of those two programs, the amount of data is considered to be statistically insignificant. However, due to CxP having LOC/LOM as key design requirements, it was necessary for Orion to generate a valid prior to begin the Risk Informed Design process. To do so, the Safety & Mission Assurance (S&MA) Space Shuttle & Exploration Analysis Section generated an initial failure probability for Orion to use in preparation for the Orion Systems Requirements Review (SRR)

Dark/Visible Parallel Universes and Big Bang Nucleosynthesis

We develop a model for visible matter-dark matter interaction based on the exchange of a massive gray boson called herein the Mulato. Our model hinges on the assumption that all known particles in the visible matter have their counterparts in the dark matter. We postulate six families of particles five of which are dark. This leads to the unavoidable postulation of six parallel worlds, the visible one and five invisible worlds. A close study of big bang nucleosynthesis (BBN), baryon asymmetries, cosmic microwave background (CMB) bounds, galaxy dynamics, together with the Standard Model assumptions, help us to set a limit on the mass and width of the new gauge boson. Modification of the statistics underlying the kinetic energy distribution of particles during the BBN is also discussed. The changes in reaction rates during the BBN due to a departure from the Debye-Hueckel electron screening model is also investigated.Comment: Invited talk at the Workshops "CompStar: the physics and astrophysics of compact stars", Tahiti, June 4-8, 2012, "New Directions in Nuclear Astrophysics", Castiglion Fiorentino, Italy, June 18-22, 2012, and "Carpathian Summer School of Physics", Sinaia, Romania, June 24 - July 7, 2012. To be published in AIP Proceeding

Processing and characterization of a polypropylene biocomposite compounded with maleated and acrylated compatibilizers

Polypropylene (PP) biocomposites containing 20wt.% sunflower hull as a particulate reinforcement were compounded and tested under tensile, flexural, and impact loadings. The incorporation of the sunflower hull without compatibilizer resulted in diminished tensile strength and impact energy absorption but increased flexural strength and both tensile modulus and flexural modulus when compared to neat PP. Formulations containing three different chemical compatibilizers were tested to determine their effectiveness in improving the interfacial adhesion between the fiber surface and PP chains. Maleic anhydride grafted with PP (MA-g-PP) achieved greater improvements in tensile strength but reduced impact strength in comparison to an acrylic-acid-grafted PP compatibilizer (AA-g-PP). The molecular weight, graft level, and the ability to affect strength, modulus, and absorbed impact energy were also investigated for the compatibilizers. A MA-g-PP having high molecular weight and low graft level was most effective in improving the investigated properties of a sunflower hull-reinforced polypropylene biocomposite

Examining parenting outcomes of childhood sexual abuse survivors utilizing observation and self-report methods.

Childhood sexual abuse (CSA) is associated with negative outcomes in adulthood, including difficulty in relationships. Research has posited CSA may lead to insecure attachment in survivors, which may be the vehicle by which dysfunctional parent-child relationships develop. The purpose of the proposed study was to examine differences in parenting outcomes between CSA and non-CSA mothers utilizing both observational and self-report methods and to examine the unique impact of CSA on parenting attitudes. Abuse status was determined by scores on the Sexual Abuse subscale of the Childhood Trauma Questionnaire (CTQ), with the CSA group comprised of mothers scoring in the moderate to severe range. Mothers self-reported parenting attitudes on the Parent-Parental Acceptance Rejection Questionnaire/Control (P-PARQ/Control) and the Adult Adolescent Parenting Inventory-2 (AAPI-2), while parental depression was assessed with the revised Beck Depression Inventory (BDI-2). Parenting behaviors were observed by coding the Parent-Child Interaction Assessment (PCIA). Hypotheses were not supported until child gender was considered as a third variable. Results of MANCOVA analyses indicated CSA mothers, but not comparison mothers, exhibited significantly poorer limit-setting skills (h² = .21) with male children compared to female children, but did not self-report these differences. Although not statistically significant, small but potentially meaningful effect sizes were found when the self-reports of CSA mothers were compared to their observed behaviors. Specifically, CSA mothers displayed increased levels of physical nurturance (h² = .11) and role reversal (h² = .08) with male children compared to female children, but again, did not self-report these differences. Finally, CSA mothers, but not comparison mothers tended to self-report greater beliefs in corporal punishment with male children compared to females (h² = .08). Secondary findings revealed parental depression was the only unique predictor of parental nurturance, attitude toward corporal punishment, and role reversal. Findings confirm the importance of third variables, including child gender and parental depression. Theoretical and clinical implications are discussed, as well as limitations and future research directions

Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion.

Estrogen receptor (ER)-negative cancers have a poor prognosis, and few targeted therapies are available for their treatment. Our previous analyses have identified potential kinase targets critical for the growth of ER-negative, progesterone receptor (PR)-negative and HER2-negative, or "triple-negative" breast cancer (TNBC). Because phosphatases regulate the function of kinase signaling pathways, in this study, we investigated whether phosphatases are also differentially expressed in ER-negative compared to those in ER-positive breast cancers. We compared RNA expression in 98 human breast cancers (56 ER-positive and 42 ER-negative) to identify phosphatases differentially expressed in ER-negative compared to those in ER-positive breast cancers. We then examined the effects of one selected phosphatase, dual specificity phosphatase 4 (DUSP4), on proliferation, cell growth, migration and invasion, and on signaling pathways using protein microarray analyses of 172 proteins, including phosphoproteins. We identified 48 phosphatase genes are significantly differentially expressed in ER-negative compared to those in ER-positive breast tumors. We discovered that 31 phosphatases were more highly expressed, while 11 were underexpressed specifically in ER-negative breast cancers. The DUSP4 gene is underexpressed in ER-negative breast cancer and is deleted in approximately 50 % of breast cancers. Induced DUSP4 expression suppresses both in vitro and in vivo growths of breast cancer cells. Our studies show that induced DUSP4 expression blocks the cell cycle at the G1/S checkpoint; inhibits ERK1/2, p38, JNK1, RB, and NFkB p65 phosphorylation; and inhibits invasiveness of TNBC cells. These results suggest that that DUSP4 is a critical regulator of the growth and invasion of triple-negative breast cancer cells

Mechanisms and regulation of surface interactions and biofilm formation in Agrobacterium

For many pathogenic bacteria surface attachment is a required first step during host interactions. Attachment can proceed to invasion of host tissue or cells or to establishment of a multicellular bacterial community known as a biofilm. The transition from a unicellular, often motile, state to a sessile, multicellular, biofilm-associated state is one of the most important developmental decisions for bacteria. Agrobacterium tumefaciens genetically transforms plant cells by transfer and integration of a segment of plasmid-encoded transferred DNA (T-DNA) into the host genome, and has also been a valuable tool for plant geneticists. A. tumefaciens attaches to and forms a complex biofilm on a variety of biotic and abiotic substrates in vitro. Although rarely studied in situ, it is hypothesized that the biofilm state plays an important functional role in the ecology of this organism. Surface attachment, motility, and cell division are coordinated through a complex regulatory network that imparts an unexpected asymmetry to the A. tumefaciens life cycle. In this review we describe the mechanisms by which A. tumefaciens associates with surfaces, and regulation of this process. We focus on the transition between flagellar-based motility and surface attachment, and on the composition, production, and secretion of multiple extracellular components that contribute to the biofilm matrix. Biofilm formation by A. tumefaciens is linked with virulence both mechanistically and through shared regulatory molecules. We detail our current understanding of these and other regulatory schemes, as well as the internal and external (environmental) cues mediating development of the biofilm state, including the second messenger cyclic-di-GMP, nutrient levels, and the role of the plant host in influencing attachment and biofilm formation. A. tumefaciens is an important model system contributing to our understanding of developmental transitions, bacterial cell biology, and biofilm formation

Theory of periodic swarming of bacteria: application to Proteus mirabilis

The periodic swarming of bacteria is one of the simplest examples for pattern formation produced by the self-organized collective behavior of a large number of organisms. In the spectacular colonies of Proteus mirabilis (the most common species exhibiting this type of growth) a series of concentric rings are developed as the bacteria multiply and swarm following a scenario periodically repeating itself. We have developed a theoretical description for this process in order to get a deeper insight into some of the typical processes governing the phenomena in systems of many interacting living units. All of our theoretical results are in excellent quantitative agreement with the complete set of available observations.Comment: 11 pages, 8 figure